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Monday, January 25, 2021
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Contrary to previous findings, low-dose aspirin therapy before conception and during early pregnancy may increase the chances of pregnancy and live birth among women who have had one or two previous miscarriages, suggests a study by researchers at the National Institutes of Instead of exclusively looking at the difference in pregnancy rates between women receiving aspirin and those receiving a placebo, the study also considered differences in total aspirin use among women who deviated from the daily regimen and those who joined it.
The research team was led by Enrique Schisterman, PhD, of the NIH Epidemiology Branch. Eunice Kennedy Shriver The National Institute for Child Health and Human Development (NICHD) and its colleagues. Appears in Annals of Internal Medicine.
Published in 2014, the study Effects of Aspirin in Pregnancy and Reproduction (EAGeR) included more than 1,000 women between the ages of 18 and 40, with one or two previous miscarriages. Women received either low-dose aspirin (81 milligrams) daily or a placebo while trying to conceive. If he conceived, he would continue to receive this regime through 36of week of pregnancy. Although the study found no overall difference in pregnancy loss rates between the two groups, there was a higher birth rate for the subgroup of women who experienced only a previous miscarriage before the 20th week of pregnancy. task.
Unlike the initial analysis, the current reanalysis considered whether a participant adhered to treatment or skipped treatment for days or stopped it altogether for side effects such as bleeding, nausea, or vomiting. Compared to the placebo group, for every 100 women, adherence to the aspirin regimen for five to seven days a week led to eight more positive pregnancy tests, with six lower pregnancy losses and culminating in another 15 live births. . Women who joined the therapy four days a week had similar results. The researchers concluded that taking small doses of aspirin at least four days a week could improve the chances of pregnancy and live birth in this group of women.
Which
Lindsey Sjaarda, PhD, scientist at the NICHD Epidemiology Branch, is available for comment.
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Naimi, AI et al. Effect of low-dose preconception-initiated aspirin on pregnancy detected by human chorionic gonadotropin, pregnancy loss, and live birth: per randomized study analysis protocol. Annals of Internal Medicine. 2021.
About Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD): NICHD conducts research and training to understand human development, improve reproductive health, improve the lives of children and adolescents, and optimize skills for all. For more information, visit https://www.nichd.nih.gov.
About the National Institutes of Health (NIH):
NIH, the national medical research agency, includes 27 institutes and centers and is a component of the US Department of Health and Human Services. NIH is the first federal agency to conduct and support basic, clinical, and translational medical research and investigate the causes, treatments, and treatments for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
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