- The Johnson & Johnson coronavirus vaccine candidate can prevent COVID-19 complications and death, as demonstrated by the findings of phase 3 study.
- Medications require a single stroke and can be stored at regular refrigerator temperatures. But the J&J COVID-19 vaccine is not as effective as the mRNA drugs from Pfizer / BioNTech and Moderna, which could be seen as a disadvantage.
- Dr. Anthony Fauci said in an interview that these comparisons do more harm than good and explained that this particular vaccine is so important.
Johnson & Johnson on Friday announced the results of its phase 3 study on the coronavirus vaccine, revealing to the world that the drug can prevent severe COVID-19 leading to hospitalization and death. The vaccine is safe to use and had no serious side effects during the massive phase 3 study. The company also said the drug will work against the South African mutation B.1.351, the only new coronavirus strain that has been shown to avoid some drugs that are already used.
The J&J vaccine has several advantages that make it a unique proposition compared to competitors. Use a one-shot regimen, this vaccinated candidate being the only one who does not require a booster shot three to four weeks after the first shot. Unlike Pfizer / BioNTech and Moderna mRNA vaccines, Johnson & Johnson vaccine can also be viewed at normal refrigeration temperatures, which means that the logistics of transporting and storing the vaccine will not be as complex.
Candidate Johnson & Johnson does not offer efficacy that fits Moderna and BioNTech drugs. But that shouldn’t be a problem, Dr. Anthony Fauci said in an interview, explaining why the new vaccine is so important to COVID-19 management in the United States and other countries.
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Fauci said CNN Friday that the J&J candidate and others will reduce stress on the US health care system. “If we can improve this, it’s really important – not only with this candidate, but also with others who have already obtained the Emergency Use Authorization (EUA),” he said.
Dr. Fauci emphasized the obvious benefits of the drug. “A cheap vaccine, which is a single dose and has no cold chain requirements – it’s pretty good,” Fauci said as he addressed the “elephant” in the room.
The effectiveness of the drug – 66% globally and 85% effective against severe diseases – fades compared to the 95% efficacy of Pfizer and Moderna. Fauci pointed out that the J&J results would look even better without an obvious comparison.
“Do you know what the problem is? If it were there and we didn’t have Moderna 94-95% …. We would have said wow, an effective vaccine with 72%, which is even more effective against severe diseases, it’s really great “, said Fauci. “But now we always judge him against 94-95%. That being said, this is a vaccine that could be used, especially in developing countries, to keep people out of the hospital. It has a very good efficacy against severe diseases. ”
The drug was 72% in the US Phase 3 volunteer group.
In the months leading up to EUAs receiving Pfizer and Moderna, Fauci and other health experts said they hoped the vaccine would be 75% effective, saying the higher the figure, the better. The FDA threshold for emergency approval has been set at 50%. The effectiveness of the flu vaccine fluctuates due to the extremely mutagenic nature of the various viruses that cause the flu, with the 2019 drug version being only 45% effective. However, the flu has other effective therapies that reduce the risk of death – not just a vaccine.
The Johnson & Johnson vaccine has another immediate advantage over the others. The phase 3 study included patients infected with at least one of the new disturbing strains. They are more infectious, and the South African strain is the only one that can steal coronavirus antibodies. It is unclear how effective the other vaccines are against this strain, with J&J being 57% effective in South Africa, where 95% of the COVID-19 cases in the study were caused by B.1.351.
Further addressing efficacy comparisons, Fauci also noted Jonson & Johnson’s research in a two-dose regimen. The company intends to see if a two-hit regime can further increase its effectiveness. “It simply came to our notice then. It could bring it up to 90%, “said the health expert. “Heck, if you had 72 with a single dose, you’d think you’d do pretty well with a boost.”
The US government already has a contract to purchase 100 million doses of Johnson & Johnson vaccine. The FDA’s EUA decision should be announced by the end of February.
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Chris Smith began writing about gadgets as a hobby, and before he knew it, he was sharing his views on technical stuff with readers around the world. Whenever he doesn’t write about gadgets, he can’t stay away from them, even though he tries desperately. But that’s not necessarily a bad thing.