Several candidates for the coronavirus vaccine have been licensed for emergency use worldwide. Most Western countries use a combination of Pfizer / BioNTech, Moderna and AstraZeneca / Oxford vaccines. Johnson & Johnson has just removed the regulatory review and the will is now available in various countries. In addition, Russia and China use their own vaccines and have exported their drugs to other markets. Nearly 276 million doses of the vaccine have been administered worldwide since Thursday morning, with 58 million people receiving the complete two-stroke regimen.
Several new studies have provided plenty of additional evidence that vaccines actually prevent severe COVID-19 and death. The drugs are also well tolerated, mainly with minimal side effects. The list of side effects includes pain at the injection site and brief flu-like symptoms. An extremely low number of allergic reactions have also been observed with certain vaccines. And now doctors have begun to notice a strange new effect of the COVID-19 vaccine, which can take more than a week to appear in some people. Fortunately, it is extremely easy and not at all worrying.
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The new symptoms appear a few days after the second blow. The arm may become red, painful, itchy and swollen, New York Times reports. The reaction appears to be harmless and should not be confused with an infection. A letter in The New England Journal of Medicine addresses the symptom, as seen in people who received the Moderna vaccine at Massachusetts General Hospital.
The letter details 12 cases of delayed skin reactions that occurred about 8 days after the first blow. The symptoms then disappeared about six days after onset. Patients were advised to continue full treatment and all completed the vaccination course. Three patients had a similar reaction after the second blow. But the skin lesions appeared faster, two days after the second blow and lasted up to three days after that.
Some of these delayed skin reactions included lesions over 10 cm in diameter. Other patients had rashes in areas of the skin that were beyond the injection site, such as the palm and elbow. Some patients also experienced fatigue and muscle aches, which are expected to have side effects that have been associated with COVID-19 vaccines. The following set of photos shows the types of skin lesions that may occur:
Some patients were treated with antihistamines, others needed steroids, and some were mistakenly prescribed an antibiotic.
The authors of the letter want to be aware of this type of side effect, so that patients and doctors know that such side effects are possible. The authors also recommend against antibiotic treatment to eliminate skin problems:
Doctors may not be prepared to address delayed local reactions to [Moderna] mRNA vaccine-1273. Given the expansion of mass vaccination campaigns worldwide, these reactions are likely to generate concerns among patients and requests for evaluation. These reactions have not been consistently recognized, guidelines for the second dose of vaccine have varied, and many patients have received unnecessary antibiotic agents. We hope that this letter encourages further reporting and communication on the epidemiological characteristics, causes and implications of these delayed skin reactions, as this information could alleviate patients’ concerns, encourage the completion of vaccination and minimize the unnecessary use of antibiotics.
Dr. Kimberly Blumenthal, one of the authors of the letter, said time that these symptoms caused Massachusetts General Hospital to change the patient’s record. “I said it’s normal to get redness, itching and swelling when you get the vaccine,” she said. “I changed the wording to say it can start seven to 10 days after you get the vaccine.” The allergy expert also said that he does not understand why the delayed skin reactions occurred only in patients who received the Moderna vaccine and not the BioNTech drug. Both are mRNA vaccines.
Massachusetts General Hospital has created a registry to track patients with delayed skin reactions. Blumenthal said about 30 cases have been observed so far, and most are women.
Moderna reported delayed skin reactions after the phase 3 study, saying that 0.8% of the volunteers experienced them after the first dose and 0.2% after the second blow. NEJM the letter shows that the Moderna process did not fully characterize these delayed reactions. Here are the most common side effects of the Modern Vaccine, as listed by the FDA:
The most commonly reported side effects, which usually lasted for several days, were pain at the injection site, fatigue, headache, muscle aches, chills, joint pain, swollen lymph nodes in the same arm as the injection, nausea and vomiting and fever. Notably, more people experienced these side effects after the second dose than after the first dose, so it is important that vaccine providers and recipients expect that there may be some side effects after any of the doses, but even more so. long after the second dose.
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Chris Smith began writing about gadgets as a hobby, and before he knew it, he was sharing his views on technical stuff with readers around the world. Whenever he doesn’t write about gadgets, he can’t stay away from them, even though he tries desperately. But that’s not necessarily a bad thing.